Dunlap MK, Kodama JK, Wellington JS, Anderson HH, Hine CH [1958]. A small amount of acrolein, a metabolic product of allyl alcohol, was detected in the bile and urine but not in ⦠Allyl alcohol (propenol). New York, NY: Academic Press, Inc., p. 86. THE TOXICITY OF ALLYL ALCOHOL CAREY P. McCORD, M.D. The Merck Index - An Encyclopedia of Chemicals, Drugs, and ⦠Allyl alcohol CAS RN: 107-18-6 Non-Human Toxicity Values. In a developmental toxicity study allyl alcohol was administered to 25 female rats (Crl:CD (SD)IGS BR) per dose by oral gavage at dose levels of 10, 35, 50 mg/kg/day fr om days 6 through 19 of gestation. Preclinical acute toxicity studies have shown that allyl alcohol causes skin and eye irritation and kidney and liver damage in animals. The toxicity of allyl alcohol. Sulfite was even more efficient in supplying sulfate for sulfate conjugation than inorganic sulfate. 1958] and animals [Dunlap et al. Human data: Severe eye irritation is reported to result from exposure at 25 ppm [Dunlap et al. Basis for original (SCP) IDLH: The chosen IDLH is based on the statement by AIHA [1963] that from animal experiments, a single 1-hour exposure to 150 ppm might be fatal, while the same exposure to 100 ppm would probably allow survival [Dunlap et al. Previous Next. 1958]. Marvin Legator, David Racusen. MECHANISM OF ALLYL ALCOHOL TOXICITY. In order to establish conditions safe for repeated exposure to these allyl compounds, essentially similar experiments were conducted with several animal species to determine the effects of prolonged inhalation of small amounts. Thank you for sharing this Journal of Bacteriology article. Inhibition or augmentation of cyclic AMP and/or protein kinase A (PKA) by Rp-Ado-3N,5N-cyclic monophosphorothioate triethylamine salt or 3-isobutyl-1-methylxanthine had no effect on allyl alcohol-induced cell death. It is also hazardous to aquatic organisms and plants. Farm Chemicals Handbook 1989. The toxicity of the alcohol (or its metabolite acrolein) is dependent on the concentration of glutathione (GSH). Basis for revised IDLH: The revised IDLH for allyl alcohol is 20 ppm based on acute inhalation toxicity data in humans [Dunlap et al. Allyl alcohol is used as a raw material for the production of glycerol, but is also used as a precursor to many specialized compounds such as flame-resistant materials, drying oils, and plasticizers. Linking to a non-federal website does not constitute an endorsement by CDC or any of its employees of the sponsors or the information and products presented on the website. Moscow, Russia: Centre of International Projects, GKNT, p. 17. 32 Allyl alcohol 1 Toxic Effects and Mode of Action Allyl alcohol is of relatively high acute toxicity. The more recent experimental works on the chemistry, industrial uses and general toxicity (with particular reference to liver cell injury) of allyl alcohol (AA) have been briefly reviewed. Short-term exposure guidelines: None developed. To determine whether heparin would affect the toxicity from a larger dose of allyl alcohol in the absence of LPS, rats that had been dosed with heparin or vehicle 3 h earlier were treated with 50 mg allyl alcohol/kg body weight (single ip injection). ASM journals are the most prominent publications in the field, delivering up-to-date and authoritative coverage of both basic and clinical microbiology. The most important adverse effects of occupational exposures to allyl alcohol ⦠Allyl alcohol. Allyl alcohol-induced toxicity only occurs after bioactivation to acrolein. AMA Arch Ind Health 18:303-311. In Annex VI of the CLP Regulation (EC No. JAMA 98(26):2269-2270. It is absorbed well by the organism after inhalation, ingestion and dermal contact, and is ⦠Back to top. NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. DOI: Article; Info & Metrics; PDF; This is a PDF-only article. Download PDF. I. JAMA, Smyth HF Jr, Carpenter CP [1948]. Allyl alcohol (IUPAC name: prop-2-en-1-ol) is an organic compound with the structural formula CH2=CHCH2OH. Belinsky SA, Badr MZ, Kauffman FC, Thurman RG. LD50 Mouse oral 85 mg/kg . LD50 Rabbit percutaneous 89 mg/kg . 1272/2008) allyl alcohol is classified as Acute toxicity Cat. We do not retain these email addresses. 107-18-6 - XXROGKLTLUQVRX-UHFFFAOYSA-N - Allyl alcohol - Similar structures search, synonyms, formulas, resource links, and other chemical information. The first page of the PDF of this article appears above. Insoluble in water and slightly less dense than water. In: Toxicology of drugs and chemicals. Embryos were injected with adh8a mRNA and exposed to 5 mg/L allyl alcohol in 24-wells (2 embryos per 2 ml). The site is secure. It is more toxic than typical small alcohols. This website and underlying databases are maintained and updated by Pesticide Action Network North America (PAN). You will be subject to the destination website's privacy policy when you follow the link. Allyl alcohol - Identification, toxicity, use, water pollution potential, ecological toxicity and regulatory information: Note: See Working with the Information on this Page section below for important notes about this data. Citation Tools, Print. Allyl acetate appears as a liquid. Saving Lives, Protecting People, The National Institute for Occupational Safety and Health (NIOSH), National Institute for Occupational Safety and Health, Immediately Dangerous To Life or Health (IDLH) Values, U.S. Department of Health & Human Services, AIHA [1963]. Further experience with the range-finding test in the industrial toxicology laboratory. McCord CP [1932]. The toxicity of allyl alcohol, assessed on the basis of release of glutamic-oxaloacetic transaminase (GOT), glutamic-pyruvic transaminase (GPT) and lactate dehydrogenase (LDH) into the culture medium, was dramatically increased by the addition of cyanamide. Time laps recording of allyl alcohol toxicity of adh8a injected embryos. Allyl alcohol may be present in natural methyl alcohol in such quantities as 0.5 per cent. Journal of Microbiology & Biology Education, Microbiology and Molecular Biology Reviews, Submission, Review, & Publication Processes. Toxic alcohols are a group of alcohols that include methanol, ethylene glycol and isopropyl alcohol. Description of substance: Colorless liquid with a pungent, mustard-like odor. Toxicometric parameters of industrial toxic chemicals under single exposure. In: Hygienic guide series. Acute and chronic toxicity. The movie shows the induced allyl alcohol toxicity through adh8a mRNA overexpression. liver lobule (10). Application Allyl alcohol may be used in the preparation of propylene via photocatalytic transfer hydrogenolysis in the presence of Pd/TiO 2 catalysts. Enter multiple addresses on separate lines or separate them with commas. AMA Arch Ind Health. Embryos were injected with adh8a mRNA and exposed to 5 mg/L allyl alcohol in 24-wells (2 embryos per 2 ml). 1958; Smyth and Carpenter 1948]. Allyl alcohol treatment alone did not significantly enhance the expression of COX-2 mRNA. Allyl alcohol can be prepared by the rhenium catalyzed-deoxydehydratio n of glycerol. This question is for testing whether or not you are a human visitor and to prevent automated spam submissions. Allyl alcohol, C 3 H 5 OH, earlier came into prominence as a toxic substance through the belief that its presence in wood alcohol (methyl alcohol) as an impurity largely accounted for the toxicity of the latter substance. Centers for Disease Control and Prevention. Mechanism of hepatotoxicity in periportal regions of the liver lobule due to allyl alcohol: studies on thiols and energy status. J Ind Hyg Toxicol. I. Moscow, Russia: Centre of International Projects, GKNT, p. 17. Pesticide Manual 6th ed LD50 Rat oral 64 mg/kg . Peroral administration of allyl alcohol to rats resulted in severe inhibition of oxygen uptake by the liver, moderate stimulation of oxygen uptake by the kidneys, and no alteration in oxygen uptake by the cerebral cortex, one and two hours after administration. Allyl alcohol exposure was performed from 8-56 hpf and mortality was measured (n = 3, see also Table S1) Movie S1 Time laps recording of allyl alcohol toxicity of adh8a injected embryos. Comparative Toxicity Studies of Allyl Acetate (CASRN 591-87-7), Allyl Alcohol (CASRN 107-18-6) and Acrolein (CASRN 107-02-8) in F344/N Rats and B6C3F1 Mice (Gavage Studies) Rats: F344/N; Mice: B6C3F1 In order to test its toxicity a monkey, rabbits and rats were exposed to atmospheres containing from 1, 000 parts of vapour per million of air down to 50 parts. McCord CP [1932]. Allyl alcohol occurs as an impurity in natural methyl alcohol and is being used as an intermediate in the chemical and pharmaceutical industries. 1958]. Therefore, the met- abolic pathways involved in the oxidative metabolism of allyl alcohol must be identified clearly. NIOSH REL: 2 ppm (5 mg/m3) TWA, 4 ppm (10 mg/m3) STEL [skin], Current OSHA PEL: 2 ppm (5 mg/m3) TWA [skin], 1989 OSHA PEL: 2 ppm (5 mg/m3) TWA, 4 ppm (10 mg/m3) STEL [skin], 1993-1994 ACGIH TLV: 2 ppm (4.8 mg/m3) TWA, 4 ppm (9.5 mg/m3) STEL [skin]. They are alcohols that should not be drunk due to various toxic effects, mostly due to toxic metabolic breakdown products. For example, carbon tetrachloride damages centrilobular regions while allyl alcohol damages periportal areas of the liver lobule (1). Am Ind Hyg Assoc J. Deichmann WB, Gerarde HW [1969]. Izmerov NF, Sanotsky IV, Sidorov KK [1982]. Sulfite was furthermore shown to be protective against the toxicity of both N-acetyl-p-benzoquinone imine (NAPQI), the reactive paracetamol metabolite, and acrolein, a reactive aldehyde which is a metabolite of allyl alcohol. The sensitivity of hepatocytes to the cytotoxicity of acrolein was also increased by 15d-PGJ 2 (Fig. CDC twenty four seven. After severe depletion of GSH, the reactive metabolite of AA can bind to essential sulfhydryl groups in the cellular macromolecules, leading to structural and functional modifications which can be responsible for cell death. A useful animal Acute and chronic toxicity. Hence floats on water. Poisonous by ingestion and moderately toxic by inhalation and skin contact. The concentration of allyl alcohol in the blood was 309 mg/L. This is a PDF-only article. The most important adverse effects of occupational exposures to allyl alcohol are upper respiratory tract irritation and burning of the eyes. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely. CINCINNATI Allyl alcohol, C3H5OH, earlier came into prominence as a toxic substance through the belief that its presence in wood alcohol (methyl alcohol) as an impurity largely accounted for the toxicity of the latter substance. 3), indicating that the effect on cytotoxicity of allyl alcohol cannot be explained simply by increased conversion to acrolein. Copyright © 2021 American Society for Microbiology | Privacy Policy | Website feedback, Print ISSN: 0021-9193; Online ISSN: 1098-5530, Sign In to Email Alerts with your Email Address. Incubation of isolated hepatocytes with allyl alcohol results in GSH depletion and subsequent cytotoxicity which is prevented by pyrazole, an inhibitor of alcohol dehydrogenase. Coagulation of the embryos was observed after 3-9 h allyl alcohol exposure. Both GSH depletion and cytotoxicity were much more rapid when hepatocytes were incubated with acrolein, the ⦠Alerts * * * Email * * * Share. The partial oxidation of allyl alcohol over oxygen-precovered gold surface was studied. The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website. Allyl alcohol, C 3 H 5 OH, earlier came into prominence as a toxic substance through the belief that its presence in wood alcohol (methyl alcohol) as an impurity largely accounted for the toxicity of the latter substance. Allyl alcohol is the smallest representative of the allylic alcohols. The toxicity of allyl alcohol. Izmerov NF, Sanotsky IV, Sidorov KK [1982]. Allyl alcohol may be present in natural methyl alcohol in such quantities as 0.5 per cent. 3 (dermal route) with an asterisk which indicates this is the minimum classification to be applied. Rates of allyl alcohol metabolism in periportal and pericentral regions of the liver lobule were measured to determine whether the zonal toxicity due to allyl alcohol results from its selective metabolism in periportal regions. CDC is not responsible for Section 508 compliance (accessibility) on other federal or private website. The first page of the PDF of this article appears above. Since the data indicates that a more severe classification is appropriate, Acute Toxicity Category 2 via the dermal route will will be applied. Allyl compounds are increasingly being used as intermediates in chemical synthesis. Allyl alcohol may be present in natural methyl alcohol in such quantities as 0.5 per cent. Like many alcohols, it is a water-soluble, colourless liquid. It has long been recognized that periportal and centrilobular regions of the liver lobule differ in their sensitivity to many hepatotoxins. Since allyl alcohol is metabolized in both regions of the liver lobule and 4-methylpyrazole lacks specificity for ADH, the mechanism of allyl alcohol toxicity requires further evaluation. The toxicity of allyl alcohol. The toxicity of allyl alcohol. The total amounts of allyl alcohol measured in urine, bile, and gastric contents were 0.5 mg, 15 mg, and 3.6 g, respectively. Toxicometric parameters of industrial toxic chemicals under single exposure. The possible involvement of thiols and adenine nucleotides in the selective toxicity to periportal regions by allyl alcohol was evaluated in isolated perfused rat livers. The purpose of these studies was to examine whether specific signal transduction pathways are associated with allyl alcohol toxicity in hepatocytes. Allyl alcohol is a colorless liquid with a pungent, mustard-like odor. 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